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Pan, X., Heacock, M. L., Abdulaziz, E. N., Violante, S., Zuckerman, A. L., Shrestha, N., Yao, C., Goodman, R. P., Cross, J. R., & Cracan, V. (2023). A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells. Nature Chemical Biology. https://doi.org/10.1038/s41589-023-01460-w
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Fomin, V., Marshall, C., Tsai, S., Goodman, R., Schaefer, E., & Luther, J. (2022). Creation of an Inpatient Alcohol Liver Service Improves Early Liver Disease Detection in Patients With Alcohol Use Disorder. Clinical Gastroenterology and Hepatology, 3–5. https://doi.org/10.1016/j.cgh.2022.03.042
Luther, J., Vannier, A. G. L., Schaefer, E. A. & Goodman, R. P. The circulating proteomic signature of alcohol-associated liver disease. JCI Insight 7, (2022).
Rath, S., Sharma, R., Gupta, R., Ast, T., Chan, C., Durham, T. J., Goodman, R. P., Grabarek, Z., Haas, M. E., Hung, W. H. W., Joshi, P. R., Jourdain, A. A., Kim, S. H., Kotrys, A. V., Lam, S. S., McCoy, J. G., Meisel, J. D., Miranda, M., Panda, A., Patgiri, A., Rogers, R., Sadre, S., Shah, H., Skinner, O. S., To, T. L., Walker, M. A., Wang, H., Ward, P. S., Wengrod, J., Yuan, C. C., Calvo, S. E., and Mootha, V. K. (2021) MitoCarta3.0: An updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 49, D1541–D1547. Pubmed
Goodman, R. P., Markhard, A. L., Shah, H., Sharma, R., Skinner, O. S., Clish, C. B., Deik, A., Patgiri, A., Hsu, Y.-H. H., Masia, R., Noh, H. L., Suk, S., Goldberger, O., Hirschhorn, J. N., Yellen, G., Kim, J. K., and Mootha, V. K. (2020) Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature. 10.1038/s41586-020-2337-2. Pubmed
Related commentary: “Letting of electrons to cope with metabolic stress”
Luther, J., Khan, S., Gala, M. K., Kedrin, D., Sridharan, G., Goodman, R. P., Garber, J. J., Masia, R., Diagacomo, E., Adams, D., King, K. R., Piaker, S., Reinecker, H.-C., Yarmush, M. L., Argemi, J., Bataller, R., Dienstag, J. L., Chung, R. T., and Patel, S. J. (2020) Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation. Proc. Natl. Acad. Sci. 117, 201911870. Pubmed
Patgiri, A., Skinner, O. S., Miyazaki, Y., Schleifer, G., Marutani, E., Shah, H., Sharma, R., Goodman, R. P., To, T. L., Robert Bao, X., Ichinose, F., Zapol, W. M., and Mootha, V. K. (2020) An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance. Nat. Biotechnol. 38, 309–313. Pubmed
Goodman, R. P., Calvo, S. E., and Mootha, V. K. (2018) Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism. J. Biol. Chem. 293, 7508–7516. Pubmed