Welcome to the Goodman lab! Our lab, based at Massachusetts General Hospital in Boston, seeks to better understand how the liver works. By doing so we hope to gain new insights into what causes liver disease, with the ultimate goal of developing new medicines and therapeutic paradigms.
Our laboratory has a particular interest in hepatic metabolism and metabolic physiology, and how alterations in specific metabolic pathways in the liver can lead to fat accumulation and inflammation in common liver conditions such as alcohol-related liver disease (ALD) and non-alcohol related fatty liver disease (NAFLD).
Our lab combines several approaches to study the liver, including cutting-edge molecular biology, metabolomics, novel culture systems, and the use of new metabolic tools to precisely alter different aspects of hepatic metabolism.